Polytechnic University of Valencia Congress, 21st International Drying Symposium

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Thermal stability of amorphous sugar matrix, dried from methanol, as an amorphous solid dispersion carrier
Koreyoshi Imamura, K. Takeda, K. Yamamoto, H. Imanaka, N. Ishida

Last modified: 02-01-2019


Developing a technique to disperse hydrophobic ingredients homogeneously in a water-soluble solid matrix (solid dispersion) is one of the topics that have been extensively investigated in the pharmaceutical and food industries. Recently, we have devised a novel solid dispersion technique (surfactant-free solid dispersion), in which a preliminarily amorphized sugar was dissolved in an organic media containing hydrophobic component, without using any surface active substances, and then vacuum dried into the amorphous solid mixture [Food Chem., 197 (2016) 1136; Mol. Pharm., 14 (2017) 791]. In this study, the physicochemical properties, especially thermal stability of the surfactant-free amorphous solid dispersion, were investigated.

keywords: solid dispersion; amorphous sugar; surfactant-free; vacuum drying; glass transition temperature

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